Search results for "WHO method"

showing 2 items of 2 documents

Low morphine doses in opioid-naive cancer patients with pain

2006

Cancer pain can be managed in most patients through the use of the analgesic ladder proposed by the World Health Organization. Recent studies have proposed to skip the second "rung" of the ladder by using a so-called "strong" opioid for moderate pain. However, usual doses of strong opioids commonly prescribed for the third rung of the analgesic ladder may pose several problems in terms of tolerability in opioid-naive patients. The aim of this multicenter study was to evaluate the efficacy and tolerability of very low doses of morphine in advanced cancer patients no longer responsive to nonopioid analgesics. A sample of 110 consecutive opioid-naive patients with moderate-to-severe pain were …

AdultMalePainWHO method cancer pain opioids morphineOpioidDose-Response RelationshipQuality of lifeNeoplasmsWHO methodMedicineHumansCancer painOpioid peptideGeneral NursingNursing (all)2901 Nursing (miscellaneous)AgedAnalgesicsDose-Response Relationship DrugCancer pain; Morphine; Opioids; WHO method; Adult; Aged; Analgesics Opioid; Dose-Response Relationship Drug; Female; Humans; Male; Middle Aged; Morphine; Neoplasms; Pain; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology (clinical); Neurology; Nursing (all)2901 Nursing (miscellaneous)Morphinebusiness.industryCancerMiddle Agedmedicine.diseaseAnalgesics OpioidClinical trialOpioidsTreatment OutcomeAnesthesiology and Pain MedicineTolerabilityOpioidNeurologyAnesthesiaMorphineFemaleNeurology (clinical)DrugbusinessCancer painmedicine.drug
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Ineffectiveness of dextromethorphan in cancer pain

1998

Experimental studies have indicated that N-methyl-D-aspartate (NMDA) receptor antagonists may be effective analgesics in a wide variety of chronic pain states. The mechanism is presumed to be related to decreased firing of dorsal horn neurons after constant repeated C-fiber stimulation. Dextromethorphan (DM), a potent NMDA antagonist with a good safety profile, may be a promising agent for the treatment of persistent pain. An open-label randomized trial was designed to examine the effects of combining DM with NSAIDs, dextropropoxyphene, or morphine in cancer patients with pain. Patients who required a change in the step of the World Health Organization's (WHO) analgesic ladder because of a …

MalePalliative careAnalgesicNeuropathic painDextromethorphanNeoplasmsWHO methodmedicineHumansCancer painGeneral NursingNursing (all)2901 Nursing (miscellaneous)DextropropoxypheneMorphinebusiness.industryPalliative CareChronic painPain scaleMiddle Agedmedicine.diseasePain IntractableAnalgesics OpioidAnesthesiology and Pain MedicineOpioidAnesthesiaNeuropathic painDrug Therapy CombinationFemaleIntractable painNeurology (clinical)businessCancer painExcitatory Amino Acid Antagonistsmedicine.drug
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